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[Efficacy of allogeneic hematopoietic stem cell transplantation in treatment of childhood myelogenous leukemia: the observation of 24 cases].
- Source :
-
Zhonghua er ke za zhi = Chinese journal of pediatrics [Zhonghua Er Ke Za Zhi] 2012 Nov; Vol. 50 (11), pp. 813-6. - Publication Year :
- 2012
-
Abstract
- Objective: To retrospectively analyze the effects of allogeneic hematopoietic stem cell transplantation (allo-HSCT) on childhood chronic myelogenous leukemia (CML).<br />Method: Of the 24 consecutive cases, 16 were boys and 8 were girls. The median age of patients was 12 (3 - 16) years old; 16 cases were in chronic phase (CP) of CML, 1 case in accelerated phase (AP) and 5 cases in blastic phase (BP). Allo-HSCT from HLA identical siblings were performed for 5 cases, HLA haplotype was performed for 14 cases and unrelated allo-HSCT for 5 cases. Twenty-four cases underwent allo-HSCT with conditioning regimen of BUCY. Prophylaxis of graft versus host disease (GVHD) included CsA + MTX plus MMF. The average follow-up was 36 months.<br />Result: All of patients were successfully engrafted. The 5-year overall survival (OS) of the 24 cases was 81%. Four patients died after allo-HSCT including 3 cases in BP from haploidentical donors and 1 case in CP from HLA identical sibling. The 5 cases who received unrelated allo-HSCT have been alive. Among the 10 cases who survived over 5 years, 3 had chronic GVHD.<br />Conclusion: Children with CML could be treated effectively with allo-HSCT. There were no significant differences among different donors. Transplantation to children with CML should be performed as early as possible. Preparative regimen adjustment before transplantation, the transplantation of associated comorbidities and effective prevention and treatment for CML patients after prolonged graft survival of high quality have important significance.
- Subjects :
- Adolescent
Child
Child, Preschool
Cyclophosphamide administration & dosage
Female
Graft vs Host Disease mortality
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive mortality
Male
Methotrexate administration & dosage
Retrospective Studies
Survival Analysis
Transplantation, Homologous
Treatment Outcome
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Graft vs Host Disease prevention & control
Hematopoietic Stem Cell Transplantation adverse effects
Hematopoietic Stem Cell Transplantation methods
Leukemia, Myelogenous, Chronic, BCR-ABL Positive therapy
Transplantation Conditioning methods
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0578-1310
- Volume :
- 50
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Zhonghua er ke za zhi = Chinese journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 23302609