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Risk of type 2 diabetes and cumulative excess weight exposure in the Framingham Offspring Study.
- Source :
-
Journal of diabetes and its complications [J Diabetes Complications] 2013 May-Jun; Vol. 27 (3), pp. 214-8. Date of Electronic Publication: 2013 Jan 10. - Publication Year :
- 2013
-
Abstract
- Aim: Mid-life obesity is associated with T2D risk. However, less is known about the cumulative effect of obesity during adulthood.<br />Methods: Framingham Offspring Study participants who had an examination at 35±2 years and were initially free of T2D were included in this study (N=1026). A cumulative excess weight (CEW) score (year*kg/m²) was calculated until T2D diagnostic or the end of follow-up.<br />Results: Eighty-four individuals (8.2%) developed T2D over 20±6 years. Mean CEW scores were 118.0±114.6 year*kg/m² in individuals who developed T2D and 30.2±91.4 year*kg/m² in those who did not develop T2D (P<0.01). T2D risk was doubled for each standard deviation increase in the CEW score (OR=1.99 [1.64-2.40]; P<0.001). However, CEW score was only significantly associated with T2D incidence for participants with a baseline BMI <25 kg/m² (OR =2.13 [1.36-3.36]; P<0.001).<br />Conclusions: Accumulating weight between the mid-thirties to the mid-fifties increases the risk of developing T2D. However, BMI in mid-thirties remains a stronger predictor of T2D risk.<br /> (Copyright © 2013 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Adult Children
Age Factors
Body Mass Index
Cohort Studies
Diabetes Mellitus, Type 2 epidemiology
Female
Follow-Up Studies
Humans
Incidence
Male
Massachusetts epidemiology
Models, Biological
Prospective Studies
Risk Factors
Diabetes Mellitus, Type 2 etiology
Obesity physiopathology
Overweight physiopathology
Weight Gain
Subjects
Details
- Language :
- English
- ISSN :
- 1873-460X
- Volume :
- 27
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of diabetes and its complications
- Publication Type :
- Academic Journal
- Accession number :
- 23312789
- Full Text :
- https://doi.org/10.1016/j.jdiacomp.2012.11.009