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Risk of type 2 diabetes and cumulative excess weight exposure in the Framingham Offspring Study.

Authors :
Bouchard DR
Porneala B
Janssen I
Langlois MF
Baillargeon JP
Fox CS
Meigs JB
D'Agostino RB Sr
Pencina M
Hivert MF
Source :
Journal of diabetes and its complications [J Diabetes Complications] 2013 May-Jun; Vol. 27 (3), pp. 214-8. Date of Electronic Publication: 2013 Jan 10.
Publication Year :
2013

Abstract

Aim: Mid-life obesity is associated with T2D risk. However, less is known about the cumulative effect of obesity during adulthood.<br />Methods: Framingham Offspring Study participants who had an examination at 35±2 years and were initially free of T2D were included in this study (N=1026). A cumulative excess weight (CEW) score (year*kg/m²) was calculated until T2D diagnostic or the end of follow-up.<br />Results: Eighty-four individuals (8.2%) developed T2D over 20±6 years. Mean CEW scores were 118.0±114.6 year*kg/m² in individuals who developed T2D and 30.2±91.4 year*kg/m² in those who did not develop T2D (P<0.01). T2D risk was doubled for each standard deviation increase in the CEW score (OR=1.99 [1.64-2.40]; P<0.001). However, CEW score was only significantly associated with T2D incidence for participants with a baseline BMI <25 kg/m² (OR =2.13 [1.36-3.36]; P<0.001).<br />Conclusions: Accumulating weight between the mid-thirties to the mid-fifties increases the risk of developing T2D. However, BMI in mid-thirties remains a stronger predictor of T2D risk.<br /> (Copyright © 2013 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1873-460X
Volume :
27
Issue :
3
Database :
MEDLINE
Journal :
Journal of diabetes and its complications
Publication Type :
Academic Journal
Accession number :
23312789
Full Text :
https://doi.org/10.1016/j.jdiacomp.2012.11.009