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The impact of prostate volume, number of biopsy cores and American Urological Association symptom score on the sensitivity of cancer detection using the Prostate Cancer Prevention Trial risk calculator.
- Source :
-
The Journal of urology [J Urol] 2013 Jul; Vol. 190 (1), pp. 70-6. Date of Electronic Publication: 2013 Jan 09. - Publication Year :
- 2013
-
Abstract
- Purpose: We assessed the independent predictive value of prostate volume, number of biopsy cores and AUASS (American Urological Association symptom score) compared to risk factors included in the PCPTRC (Prostate Cancer Prevention Trial risk calculator for prostate cancer) and PCPTHG (Prostate Cancer Prevention Trial risk calculator for high grade cancer [Gleason grade 7 or greater]).<br />Materials and Methods: Of 5,519 PCPT (Prostate Cancer Prevention Trial) participants used to construct the PCPTRC 4,958 with AUASS and prostate specific antigen 10 ng/ml or less were included on logistic regression analysis. Risk algorithms were evaluated in 571 EDRN (Early Detection Research Network) participants using the ROC AUC.<br />Results: A total of 1,094 participants (22.1%) had prostate cancer, of whom 232 (21.2%) had high grade disease. For prostate cancer prediction higher prostate specific antigen, abnormal digital rectal examination, family history of prostate cancer and number of cores were associated with increased risk, while volume was associated with decreased risk. Excluding prostate volume and number of cores, a history of negative biopsy and increased AUASS were also associated with lower risk. For high grade cancer higher prostate specific antigen, abnormal digital rectal examination, black race and number of cores were associated with increased risk and volume, while AUASS was associated with decreased risk. The AUC of the PCPTRC adjusted for volume and number of cores was 72.7% (using EDRN data), 68.2% when adjusted for AUASS alone and 67.6% PCPTRC. For high grade disease the AUCs were 74.8%, 74.0% and 73.5% (PCPTHG), respectively.<br />Conclusions: Adjusted PCPT risk calculators for volume, number of cores and AUASS improve cancer detection.<br /> (Copyright © 2013 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Algorithms
Bayes Theorem
Biopsy, Large-Core Needle statistics & numerical data
Cohort Studies
Digital Rectal Examination
Early Diagnosis
Humans
Logistic Models
Male
Middle Aged
Neoplasm Staging
Prostatic Neoplasms blood
Prostatic Neoplasms prevention & control
ROC Curve
Registries
Risk Assessment
Sensitivity and Specificity
Societies, Medical
United States
Practice Guidelines as Topic
Prostate-Specific Antigen blood
Prostatic Neoplasms pathology
Tumor Burden physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1527-3792
- Volume :
- 190
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of urology
- Publication Type :
- Academic Journal
- Accession number :
- 23313212
- Full Text :
- https://doi.org/10.1016/j.juro.2012.12.108