Back to Search
Start Over
Interferon induction and suppression in swine testicle cells by porcine parvovirus and its proteins.
- Source :
-
Veterinary microbiology [Vet Microbiol] 2013 Apr 12; Vol. 163 (1-2), pp. 157-61. Date of Electronic Publication: 2012 Nov 29. - Publication Year :
- 2013
-
Abstract
- Porcine parvovirus (PPV) is a major causative agent of reproductive failure in swine, which currently affects the swine industry worldwide. Although PPV was identified several years ago, little is known about how it overcomes host innate immunity. In this study, we used quantitative real-time PCR and a luciferase reporter assay to determine whether PPV infection induces type I interferon (IFN-α and IFN-β) and whether PPV infection blocks dsRNA-induced IFN-β promoter activation in cell cultures. The results indicate that PPV does not induce type I interferon and that the NS2 protein of PPV could blocks dsRNA-induced IFN-β promoter activation.<br /> (Copyright © 2012 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Cell Line
Immunity, Innate
Male
Parvoviridae Infections immunology
Parvoviridae Infections virology
Poly I-C immunology
Promoter Regions, Genetic genetics
RNA, Double-Stranded metabolism
Swine
Swine Diseases virology
Testis cytology
Time Factors
Virus Replication
Gene Expression Regulation
Interferons genetics
Parvoviridae Infections veterinary
Parvovirus, Porcine immunology
Swine Diseases immunology
Testis virology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2542
- Volume :
- 163
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Veterinary microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 23333362
- Full Text :
- https://doi.org/10.1016/j.vetmic.2012.11.032