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Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance.
- Source :
-
Genes & development [Genes Dev] 2013 Jan 15; Vol. 27 (2), pp. 157-62. - Publication Year :
- 2013
-
Abstract
- Eukaryotes employ elaborate mitochondrial quality control (MQC) to maintain the function of the power-generating organelle. Parkinson's disease-associated PINK1 and Parkin actively participate in MQC. However, the signaling events involved are largely unknown. Here we show that mechanistic target of rapamycin 2 (mTORC2) and Tricornered (Trc) kinases act downstream from PINK1 to regulate MQC. Trc is phosphorylated in mTORC2-dependent and mTORC2-independent manners and is specifically localized to mitochondria in response to PINK1, which regulates mTORC2 through mitochondrial complex-I activity. Genetically, mTORC2 and Trc act upstream of Parkin. Thus, multiplex kinase signaling is acting between PINK1 and Parkin to regulate MQC, a process highly conserved in mammals.
Details
- Language :
- English
- ISSN :
- 1549-5477
- Volume :
- 27
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Genes & development
- Publication Type :
- Academic Journal
- Accession number :
- 23348839
- Full Text :
- https://doi.org/10.1101/gad.203406.112