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Photoaffinity casting of a coumarin flag for rapid identification of ligand-binding sites within protein.
Photoaffinity casting of a coumarin flag for rapid identification of ligand-binding sites within protein.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2013 Mar 04; Vol. 49 (18), pp. 1811-3. Date of Electronic Publication: 2013 Jan 25. - Publication Year :
- 2013
-
Abstract
- A photo-switchable fluorescent flagging approach has been developed to identify photoaffinity-labeled peptides in target protein. Upon photochemical release of the ligand, the protein was newly modified with a coumarin in place of the previously attached biotin. It allowed us to simplify complex identification processes for labeled sites.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 49
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 23349004
- Full Text :
- https://doi.org/10.1039/c3cc38594a