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Spleen size measured on enhanced MRI for quantitatively staging liver fibrosis in minipigs.
- Source :
-
Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2013 Sep; Vol. 38 (3), pp. 540-7. Date of Electronic Publication: 2013 Jan 24. - Publication Year :
- 2013
-
Abstract
- Purpose: To investigate whether and how spleen size measured on magnetic resonance imaging (MRI) could be used to stage liver fibrosis.<br />Materials and Methods: Sixteen minipigs were used to prospectively model liver fibrosis staged by biopsy. Abdominal gadolinium-enhanced MRI was performed on the 0, 5th, 9th, 16th, and 21st weekend after beginning of the modeling. Splenic maximal width (W), thickness (T), length (L), and area (S) together with spleen volume (SV) and liver volume (LV) were measured on enhanced MRI and the ratio of SV to LV (SV/LV) was calculated. Spleen multidimensional indexes 1 and 2 were obtained by W × T × L and S × L, respectively. Statistical analyses were performed to determine which parameter could best stage the fibrosis.<br />Results: W, T, L, S, SV, index 1 and 2, and SV/LV tended to increase with increasing stages of fibrosis (r = 0.46-0.796, all P < 0.001), and might predict liver fibrosis stage ≥1, ≥2, ≥3, and 4 (area under receiver operating characteristic curve [AUC] = 0.697-1.0, all P < 0.05). Among the parameters, splenic index 1, SV, and SV/LV might be best for predicting stage ≥1 (AUC = 0.941), ≥2 or ≥3 (AUC = 0.875 or 0.978, respectively), and 4 (AUC = 1.0), respectively.<br />Conclusion: Spleen size measured on MRI could be used for staging liver fibrosis.<br /> (Copyright © 2012 Wiley Periodicals, Inc., a Wiley company.)
- Subjects :
- Algorithms
Animals
Contrast Media
Female
Image Enhancement methods
Image Interpretation, Computer-Assisted methods
Imaging, Three-Dimensional methods
Male
Organ Size
Reproducibility of Results
Sensitivity and Specificity
Swine
Swine, Miniature
Gadolinium DTPA
Liver Cirrhosis complications
Liver Cirrhosis pathology
Magnetic Resonance Imaging methods
Spleen pathology
Splenomegaly etiology
Splenomegaly pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1522-2586
- Volume :
- 38
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of magnetic resonance imaging : JMRI
- Publication Type :
- Academic Journal
- Accession number :
- 23349034
- Full Text :
- https://doi.org/10.1002/jmri.24007