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Investigation of the ZNF804A gene polymorphism with genetic risk for bipolar disorder in attention deficit hyperactivity disorder.
- Source :
-
BMC research notes [BMC Res Notes] 2013 Jan 26; Vol. 6, pp. 29. Date of Electronic Publication: 2013 Jan 26. - Publication Year :
- 2013
-
Abstract
- Background: Genome-wide association studies (GWAS) have been conducted on many psychiatric disorders. Evidence from large GWAS indicates that the single nucleotide polymorphism (SNP) rs1344706 in the zinc-finger protein 804A gene (ZNF804A) is associated with psychotic disorders including bipolar disorder and schizophrenia. One study also found significant association between rs1344706 and the executive control network of attention. In this study we examine the role of the rs1344706 polymorphism that previously showed association with BD and is known to alter expression of the gene in two clinical family-based ADHD samples from the UK and Taiwan.<br />Findings: To investigate the association between rs1344706 and ADHD, two family samples of ADHD probands from the United Kingdom (n = 180) and Taiwan (n = 212) were genotyped using TaqMan SNP genotyping assays and analysed using within-family transmission disequilibrium test. No significant associations were found between rs1344706 polymorphism and ADHD in either of the samples from Taiwan (P = 0.91) and UK (P = 0.41). Even combining the two datasets together the A allele of rs1344706 SNP was still not significantly over-transmitted to affected probands (P = 0.50). Furthermore, there was no evidence of association with the specific symptoms subgroups of inattention or hyperactivity-impulsivity.<br />Conclusions: In this study we used family-based ADHD data in the UK and Taiwanese population to test for an association between rs1344706 SNP in the ZNF804A gene and ADHD. Results showed no significant association of rs1344706 with ADHD in UK and Taiwanese samples.
- Subjects :
- Adolescent
Attention Deficit Disorder with Hyperactivity complications
Bipolar Disorder complications
Child
Child, Preschool
Female
Genome-Wide Association Study
Humans
Male
Taiwan
United Kingdom
Attention Deficit Disorder with Hyperactivity genetics
Bipolar Disorder genetics
Genetic Predisposition to Disease
Kruppel-Like Transcription Factors genetics
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1756-0500
- Volume :
- 6
- Database :
- MEDLINE
- Journal :
- BMC research notes
- Publication Type :
- Academic Journal
- Accession number :
- 23351715
- Full Text :
- https://doi.org/10.1186/1756-0500-6-29