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Intravitreal bevacizumab for retinal neovascularizations associated with myelinated nerve fibers.
- Source :
-
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics [J Ocul Pharmacol Ther] 2013 May; Vol. 29 (4), pp. 442-3. Date of Electronic Publication: 2013 Jan 30. - Publication Year :
- 2013
-
Abstract
- Purpose: To report the effects of intravitreal bevacizumab injection (IVBI) in a patient affected by retinal neovascularizations (RNVs) associated with myelinated nerve fibers (MNF) and complicated by vitreous hemorrhage.<br />Methods: A 23-year-old female was referred because of sudden visual acuity deterioration in the left eye. Nine years earlier, the subject underwent retinal laser photocoagulation for recurrent vitreous hemorrhages related to the development of RNV associated with MNF. The ophthalmological evaluation revealed a new recurrence of vitreous hemorrhage associated with fluorescein leakage from RNV. After careful discussion, the patient underwent IVBI.<br />Results: One month after the injection, the best corrected visual acuity (BCVA) improved from 20/400 to 20/100, with a vitreous hemorrhage resolution, and cessation of fluorescein leakage. Over the 24-month follow-up, 2 additional IVBIs were administered due to further vitreous hemorrhage associated with fluorescein leakage from RNV, achieving a final BCVA of 20/80.<br />Conclusions: IVBI may temporarily counteract the vascular hyperpermeability typical of RNV associated with MNF, leading to the cessation of fluorescein leakage, but does not result in RNV regression.
- Subjects :
- Angiogenesis Inhibitors administration & dosage
Antibodies, Monoclonal, Humanized administration & dosage
Bevacizumab
Female
Fluorescein metabolism
Fluorescein Angiography
Follow-Up Studies
Humans
Intravitreal Injections
Retinal Neovascularization pathology
Visual Acuity drug effects
Vitreous Hemorrhage drug therapy
Young Adult
Angiogenesis Inhibitors therapeutic use
Antibodies, Monoclonal, Humanized therapeutic use
Nerve Fibers, Myelinated pathology
Retinal Neovascularization drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1557-7732
- Volume :
- 29
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 23362796
- Full Text :
- https://doi.org/10.1089/jop.2012.0094