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Butyrate supplementation to gestating sows and piglets induces muscle and adipose tissue oxidative genes and improves growth performance.
- Source :
-
Journal of animal science [J Anim Sci] 2012 Dec; Vol. 90 Suppl 4, pp. 430-2. - Publication Year :
- 2012
-
Abstract
- Weaned pigs often experience growth reduction immediately after weaning due to multiple stress factors associated with weaning. We tested the effect of prenatal and postnatal butyrate supplementation on growth performance of piglets. In study 1, piglets were orally gavaged with 0.3% butyrate from day 4 after birth to weaning (day 21). Butyrate increased ADG by 13% compared to saline treated control. Expression of peroxisome proliferator activated receptor gamma coactivator 1 alpha (PGC-1α) was higher in muscle, adipose tissue, and ileum of butyrate-supplemented animals. Also, peroxisome proliferator activated receptor alpha (PPARα) was induced (P < 0.05) in the subcutaneous adipose tissue (SCAT) and muscle (longissimus dorsi [LD]) of butyrate-supplemented piglets. In vitro, butyrate increased (P < 0.05) fatty acid oxidation in primary adipocytes and suppressed basal lipolysis by 62% compared to untreated cells. Butyrate suppressed (P < 0.05) lipogenesis ((14)C-glucose incorporation into lipids) in adipocytes. This was accompanied by an approximately 30% reduction in the mRNA expression of fatty acid synthase (P < 0.05) in butyrate-treated cells vs. controls. Piglets born to sows that were supplemented with 0.3% butyrate during the last trimester of gestation had a 15% higher (P < 0.05) body weight at 12 wk than controls. In summary, butyrate supplementation to gestating sows and piglets enhanced postweaning growth performance, which may be mediated by increased substrate oxidation in butyrate treated animals.
- Subjects :
- Animal Nutritional Physiological Phenomena
Animals
Butyrates administration & dosage
Diet veterinary
Dietary Supplements
Female
Male
Oxidative Stress
Pregnancy
Swine physiology
Adipose Tissue metabolism
Animal Feed analysis
Butyrates pharmacology
Gene Expression Regulation drug effects
Muscle, Skeletal metabolism
Swine growth & development
Subjects
Details
- Language :
- English
- ISSN :
- 1525-3163
- Volume :
- 90 Suppl 4
- Database :
- MEDLINE
- Journal :
- Journal of animal science
- Publication Type :
- Academic Journal
- Accession number :
- 23365400
- Full Text :
- https://doi.org/10.2527/jas.53817