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The maximum standardized uptake value of 18 F-FDG PET scan to determine prognosis of hormone-receptor positive metastatic breast cancer.
- Source :
-
BMC cancer [BMC Cancer] 2013 Jan 31; Vol. 13, pp. 42. Date of Electronic Publication: 2013 Jan 31. - Publication Year :
- 2013
-
Abstract
- Background: Whether PET scan maximum standard uptake value (SUVmax) could differentiate luminal A from luminal B and help predict the survival of metastatic breast cancer (MBC) patients with luminal subtype is still unknown and need to be investigated.<br />Methods: 305 MBC patients with luminal subtypes were screened with PET/CT. Eligible patients were prospectively followed up.<br />Results: In total, 134 patients were eligible for this study. SUVmax was significantly related to the number of metastatic sites and presence of visceral metastasis on univariate analysis. SUVmax could not effectively differentiate patients with luminal A from luminal B subtype. Although luminal subtype at diagnosis could predict the relapse-free interval, it could not predict progression-free survival (PFS) or overall survival (OS) after developing relapse. In contrast, SUVmax was predictive of both PFS and OS and this effect was maintained in multivariate COX regression model.<br />Conclusions: SUVmax of MBC did not correlate with molecular subtypes of primary tumor. While molecular subtype may be a valuable prognostic factor at primary diagnosis of breast cancer, the SUVmax, rather than molecular subtype, does have a potential to predict independently in multivariate analysis for the PFS and OS in patients with metastatic disease of luminal subtype.
- Subjects :
- Adult
Aged
Breast Neoplasms metabolism
Breast Neoplasms pathology
Disease-Free Survival
Female
Humans
Lymphatic Metastasis
Middle Aged
Positron-Emission Tomography methods
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Prospective Studies
Receptors, Estrogen metabolism
Receptors, Progesterone metabolism
Breast Neoplasms diagnostic imaging
Fluorodeoxyglucose F18 pharmacokinetics
Radiopharmaceuticals pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2407
- Volume :
- 13
- Database :
- MEDLINE
- Journal :
- BMC cancer
- Publication Type :
- Academic Journal
- Accession number :
- 23368410
- Full Text :
- https://doi.org/10.1186/1471-2407-13-42