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The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs.
- Source :
-
Journal of neurology, neurosurgery, and psychiatry [J Neurol Neurosurg Psychiatry] 2013 Jun; Vol. 84 (6), pp. 637-43. Date of Electronic Publication: 2013 Jan 31. - Publication Year :
- 2013
-
Abstract
- The aim of this study was to compare the prevalence of diagnosed neurodevelopmental disorders in children exposed, in utero, to different antiepileptic drug treatments. A prospective cohort of women with epilepsy and a control group of women without epilepsy were recruited from antenatal clinics. The children of this cohort were followed longitudinally until 6 years of age (n=415). Diagnosis of a neurodevelopmental disorder was made independently of the research team. Multiple logistic regression analysis revealed an increase in risk of neurodevelopmental disorders in children exposed to monotherapy sodium valproate (VPA) (6/50, 12.0%; aOR 6.05, 95%CI 1.65 to 24.53, p=0.007) and in those exposed to polytherapy with sodium VPA (3/20, 15.0%; aOR 9.97, 95% CI 1.82 to 49.40, p=0.005) compared with control children (4/214; 1.87%). Autistic spectrum disorder was the most frequent diagnosis. No significant increase was found among children exposed to carbamazepine (1/50) or lamotrigine (2/30). An accumulation of evidence demonstrates that the risks associated with prenatal sodium VPA exposure include an increased prevalence of neurodevelopmental disorders. Whether such disorders are discrete or represent the severe end of a continuum of altered neurodevelopmental functioning requires further investigation. Replication and extension of this research is required to investigate the mechanism(s) underpinning the relationship. Finally, the increased likelihood of neurodevelopmental disorders should be communicated to women for whom sodium VPA is a treatment option.
- Subjects :
- Adult
Carbamazepine adverse effects
Case-Control Studies
Child
Child Development Disorders, Pervasive chemically induced
Child Development Disorders, Pervasive epidemiology
Child, Preschool
Developmental Disabilities epidemiology
Female
Humans
Infant
Lamotrigine
Logistic Models
Pregnancy
Prevalence
Prospective Studies
Risk Factors
Triazines adverse effects
Valproic Acid adverse effects
Anticonvulsants adverse effects
Developmental Disabilities chemically induced
Prenatal Exposure Delayed Effects chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 1468-330X
- Volume :
- 84
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of neurology, neurosurgery, and psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 23370617
- Full Text :
- https://doi.org/10.1136/jnnp-2012-304270