B- and T-lymphocyte attenuator/herpes virus entry mediator as early indicators for acute rejection following kidney transplantation.

Authors :: Tian Ch
Liu YG
Yan JK
Liu SD
Zhao ST
Wang HW
Source :: Transplantation proceedings [Transplant Proc] 2013 Jan-Feb; Vol. 45 (1), pp. 157-62.
Publication Year :: 2013
Abstract: Objective: The objective of this study was to investigate the roles of B- and T-lymphocyte attenuator (BTLA) and herpes virus entry mediator (HVEM) in acute and chronic transplant rejection and immune tolerance.<br />Methods: The expression patterns of BTLA/HVEM, interleukin (IL)-2, IL-4, IL-10, and interferon (IFN)-γ were analyzed among patients presenting with acute rejection episodes versus those maintaining stable renal function during therapy with mycophenolate mofetil (MMF), cyclosporine, or tacrolimus (FK506) plus prednisolone.<br />Results: The expressions of BTLA/HVEM in the rejection group were obviously increased compared with the stable group (P < .05), followed by the elevation of serum levels of IL-2 and IFN-γ.<br />Conclusion: The expression levels of BTLA/HVEM can be considered to be early indicators of an acute rejection episode following kidney transplantation.<br /> (Copyright © 2013 Elsevier Inc. All rights reserved.)

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