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Role of different replacement fluids during extracorporeal treatment in a pig model of sepsis.
- Source :
-
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy [Ther Apher Dial] 2013 Feb; Vol. 17 (1), pp. 84-92. Date of Electronic Publication: 2012 Aug 29. - Publication Year :
- 2013
-
Abstract
- In an extracorporeal combination therapy, the impact of different replacement fluids on survival was tested in a bacterial sepsis model in pigs. In an animal study 19 pigs, weighing 7.5-11.1 kg, were included. All groups received an intravenous lethal dose of live Staphylococcus aureus over 1 h. The animals were treated by an extracorporeal circuit consisting of online centrifugation and subsequent plasma filtration for 4 h. The extracorporeal circuit was pre-filled with 400 mL replacement fluid. In the P0 group 100% hydroxyethyl starch 130/0.4 was used as replacement fluid; in the P30 group 30% pig plasma and 70% hydroxyethyl starch; and in the P100 group 100% pig plasma. The observation time was 7 days. All animals of the group P100 survived, while all animals of group P0 and five out of seven animals of the P30 group died during the observation time. Extracorporeal therapy consisting of online centrifugation and plasma filtration with 100% pig plasma as replacement fluid significantly improved survival in a pig model of sepsis. Further studies with this approach are encouraged.<br /> (© 2012 The Authors. Therapeutic Apheresis and Dialysis © 2012 International Society for Apheresis.)
- Subjects :
- Animals
Disease Models, Animal
Female
Hydroxyethyl Starch Derivatives administration & dosage
Plasma Substitutes administration & dosage
Sepsis microbiology
Staphylococcal Infections microbiology
Staphylococcus aureus isolation & purification
Survival Rate
Swine
Extracorporeal Circulation methods
Fluid Therapy methods
Sepsis therapy
Staphylococcal Infections therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1744-9987
- Volume :
- 17
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
- Publication Type :
- Academic Journal
- Accession number :
- 23379499
- Full Text :
- https://doi.org/10.1111/j.1744-9987.2012.01103.x