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Renalase protects against ischemic AKI.

Authors :
Lee HT
Kim JY
Kim M
Wang P
Tang L
Baroni S
D'Agati VD
Desir GV
Source :
Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2013 Feb; Vol. 24 (3), pp. 445-55. Date of Electronic Publication: 2013 Feb 07.
Publication Year :
2013

Abstract

Elevated levels of plasma catecholamines accompany ischemic AKI, possibly contributing the inflammatory response. Renalase, an amine oxidase secreted by the proximal tubule, degrades circulating catecholamines and reduces myocardial necrosis, suggesting that it may protect against renal ischemia reperfusion injury. Here, mice subjected to renal ischemia reperfusion injury had significantly lower levels of renalase in the plasma and kidney compared with sham-operated mice. Consistent with this, plasma NE levels increased significantly after renal ischemia reperfusion injury. Furthermore, renal tubular inflammation, necrosis, and apoptosis were more severe and plasma catecholamine levels were higher in renalase-deficient mice subjected to renal ischemia reperfusion compared with wild-type mice. Administration of recombinant human renalase reduced plasma catecholamine levels and ameliorated ischemic AKI in wild-type mice. Taken together, these data suggest that renalase protects against ischemic AKI by reducing renal tubular necrosis, apoptosis, and inflammation, and that plasma renalase might be a biomarker for AKI. Recombinant renalase therapy may have potential for the prevention and treatment of AKI.

Details

Language :
English
ISSN :
1533-3450
Volume :
24
Issue :
3
Database :
MEDLINE
Journal :
Journal of the American Society of Nephrology : JASN
Publication Type :
Academic Journal
Accession number :
23393318
Full Text :
https://doi.org/10.1681/ASN.2012090943