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Impaired glucose metabolism is a risk factor for increased thyroid volume and nodule prevalence in a mild-to-moderate iodine deficient area.
- Source :
-
Metabolism: clinical and experimental [Metabolism] 2013 Jul; Vol. 62 (7), pp. 970-5. Date of Electronic Publication: 2013 Feb 05. - Publication Year :
- 2013
-
Abstract
- Objective: Insulin resistance (IR) is a key factor involved in the pathogenesis of impaired glucose metabolism. IR is associated with increased thyroid volume and nodule prevalence in patients with metabolic syndrome. Data on the association of thyroid morphology and abnormal glucose metabolism are limited. This prospective study was carried out to evaluate thyroid volume and nodule prevalence in patients with pre-diabetes and type 2 diabetes mellitus (DM) in a mild-to-moderate iodine deficient area.<br />Materials and Methods: Data were gathered on all newly diagnosed patients with pre-diabetes and type 2 diabetes mellitus between May 2008 and February 2010. 156 patients with pre-diabetes and 123 patients with type 2 DM were randomly matched for age, gender, and smoking habits with 114 subjects with normal glucose metabolism. Serum thyroid-stimulating hormone (TSH) and thyroid ultrasonography was performed in all participants.<br />Results: Mean TSH level in the diabetes group (1.9±0.9 mIU/L) was higher than in the control group (1.4±0.8 mIU/L) and the pre-diabetes group (1.5±0.8 mIU/L) (P<0.0001 for both). Mean thyroid volume was higher in the pre-diabetes (18.2±9.2mL) and diabetes (20.0±8.2mL) groups than in controls (11.4±3.8mL) (P<0.0001 for both). Percentage of patients with thyroid nodules was also higher in the pre-diabetes (51.3%) and diabetes groups (61.8%) than in controls (23.7%) (P<0.0001 for both).<br />Conclusions: The results suggest that patients with impaired glucose metabolism have significantly increased thyroid volume and nodule prevalence.<br /> (Copyright © 2013 Elsevier Inc. All rights reserved.)
- Subjects :
- Autoantibodies blood
Case-Control Studies
Female
Goiter, Endemic complications
Goiter, Endemic epidemiology
Goiter, Endemic metabolism
Humans
Immunoglobulins, Thyroid-Stimulating analysis
Iodine urine
Male
Middle Aged
Organ Size
Prevalence
Prospective Studies
Risk Factors
Thyroid Gland immunology
Thyroid Gland metabolism
Thyroid Nodule complications
Thyroid Nodule epidemiology
Thyroid Nodule metabolism
Thyrotropin blood
Thyrotropin metabolism
Turkey epidemiology
Diabetes Mellitus, Type 2 complications
Goiter, Endemic pathology
Insulin Resistance
Iodine deficiency
Prediabetic State complications
Thyroid Gland pathology
Thyroid Nodule pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8600
- Volume :
- 62
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Metabolism: clinical and experimental
- Publication Type :
- Academic Journal
- Accession number :
- 23395200
- Full Text :
- https://doi.org/10.1016/j.metabol.2013.01.009