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Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents.
- Source :
-
PloS one [PLoS One] 2013; Vol. 8 (2), pp. e56475. Date of Electronic Publication: 2013 Feb 13. - Publication Year :
- 2013
-
Abstract
- A series of trans-3-aryl acrylic acids 1-27 and their derivatives 28-34 were prepared and evaluated for their antiviral activity against tobacco mosaic virus (TMV) for the first time. The bioassay results showed that most of these compounds exhibited good antiviral activity against TMV, of which compounds 1, 5, 6, 20, 27 and 34 exhibited significantly higher activity against TMV than commercial Ribavirin both in vitro and in vivo. Furthermore, these compounds have more simple structure than commercial Ribavirin, and can be synthesized more efficiently. These new findings demonstrate that trans-3-aryl acrylic acids and their derivatives represent a new template for antiviral studies and could be considered for novel therapy against plant virus infection.
- Subjects :
- Acrylates chemistry
Antiviral Agents chemistry
Caffeic Acids chemistry
Caffeic Acids pharmacology
Cinnamates chemistry
Cinnamates pharmacology
Coumaric Acids chemistry
Coumaric Acids pharmacology
Drug Discovery
Models, Chemical
Molecular Structure
Plant Leaves virology
Ribavirin chemistry
Ribavirin pharmacology
Structure-Activity Relationship
Nicotiana virology
Tobacco Mosaic Virus physiology
Vanillic Acid chemistry
Vanillic Acid pharmacology
Acrylates pharmacology
Antiviral Agents pharmacology
Host-Pathogen Interactions drug effects
Tobacco Mosaic Virus drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 8
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 23418574
- Full Text :
- https://doi.org/10.1371/journal.pone.0056475