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Serum C1q- binding adiponectin in maintenance hemodialysis patients.
- Source :
-
BMC nephrology [BMC Nephrol] 2013 Feb 26; Vol. 14, pp. 50. Date of Electronic Publication: 2013 Feb 26. - Publication Year :
- 2013
-
Abstract
- Background: Patients on maintenance hemodialysis (HD) have much higher levels of adiponectin (Total-APN). Adiponectin and C1q form a protein complex in human blood, and serum C1q-binding adiponectin (C1q-APN) can be measured. We recently reported that C1q-APN/Total-APN ratio rather than Total-APN correlated with atherosclerosis in diabetics. However, the characteristics of C1q-APN in HD patients remain unclear. The preset study investigated the characteristics of the adiponectin parameters including C1q-APN and also to clarify the relationship between various serum adiponectin parameters and atherosclerotic cardiovascular diseases (ACVD) in HD patients.<br />Methods: The single cross-sectional study subjects were 117 Japanese patients (males/females = 61/56) on regular HD. Blood Total-APN, high molecular weight-adiponectin (HMW-APN), C1q-APN and C1q concentrations were measured by enzyme-linked immunosorbent assays. ACVD were defined as stroke, coronary and peripheral artery diseases, thoracic and abdominal aneurysms.<br />Results: Stepwise regression analysis identified high-density lipoprotein-cholesterol (HDL-C) as the only significant and independent determinant of C1q-APN in males, and duration of HD as the only significant and independent determinant of C1q-APN in females. Stepwise regression analysis identified uric acid, low-density lipoprotein-cholesterol and triglyceride as significant and independent determinants of C1q-APN/Total-APN ratio in males, and leukocyte count and HDL-C as significant and independent determinants of C1q-APN/Total-APN ratio in females. Multiple logistic regression analysis identified inorganic phosphorus and C1q-APN or C1q-APN/C1q ratio as significant determinants of ACVD.<br />Conclusions: Low serum C1q-APN and C1q-APN/C1q ratio, but not C1q-APN/Total-APN ratio, correlated with ACVD in HD patients.<br />Trial Registration: ClinicalTrials.gov: UMIN http://000004318.
- Subjects :
- Adult
Aged
Aged, 80 and over
Comorbidity
Female
Humans
Japan epidemiology
Male
Middle Aged
Renal Insufficiency, Chronic epidemiology
Treatment Outcome
Adiponectin blood
Complement C1q metabolism
Coronary Artery Disease blood
Coronary Artery Disease epidemiology
Renal Dialysis statistics & numerical data
Renal Insufficiency, Chronic blood
Renal Insufficiency, Chronic rehabilitation
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2369
- Volume :
- 14
- Database :
- MEDLINE
- Journal :
- BMC nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 23442371
- Full Text :
- https://doi.org/10.1186/1471-2369-14-50