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Chunggan extract (CGX), a traditional Korean herbal medicine, exerts hepatoprotective effects in a rat model of chronic alcohol consumption.
- Source :
-
Phytotherapy research : PTR [Phytother Res] 2013 Dec; Vol. 27 (12), pp. 1854-62. Date of Electronic Publication: 2013 Mar 04. - Publication Year :
- 2013
-
Abstract
- Chunggan extract, CGX, is a modification of a traditional herbal medicine that has been used for patients suffering from various liver disorders since 2001. Here, we investigated the hepatoprotective effects of CGX and its underlying mechanisms in a rat model of chronic alcohol consumption. Rats were orally administered 30% ethanol solution for 4 weeks with or without CGX (50, 100, 200 mg/kg). The histopathology, biochemistry, oxidative stress/antioxidant biomarkers, hepatofibrogenic cytokines, and serum endotoxin level were analyzed. Alcohol treatment markedly elevated the serum levels of aspartate transaminase, alkaline phosphatase, and total reactive oxygen species, and tissue levels of hydroxyproline and malondialdehyde (MDA), while reducing the total glutathione (GSH) contents and the activities of superoxide dismutase and catalase. These alterations were significantly attenuated by CGX treatment (mainly 100 and 200 mg/kg). CGX treatment normalized the elevation of fibrogenic cytokines, including transforming growth factor-β, platelet derived growth factor-β, and connective tissue growth factor in hepatic tissues and ameliorated the increase in serum endotoxin concentration. These results suggest that CGX protects liver tissue from alcohol injury through antioxidant actions and prevention of endotoxin reflux. .<br /> (Copyright © 2013 John Wiley & Sons, Ltd.)
- Subjects :
- Alcohol Drinking adverse effects
Animals
Antioxidants metabolism
Biomarkers blood
Biomarkers metabolism
Cytokines metabolism
Male
Medicine, Korean Traditional
Plant Extracts therapeutic use
Protective Agents therapeutic use
Rats
Rats, Sprague-Dawley
Chemical and Drug Induced Liver Injury drug therapy
Oxidative Stress drug effects
Phytotherapy
Plant Extracts pharmacology
Protective Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1099-1573
- Volume :
- 27
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Phytotherapy research : PTR
- Publication Type :
- Academic Journal
- Accession number :
- 23460575
- Full Text :
- https://doi.org/10.1002/ptr.4935