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Neuromuscular blocking effect of fluoxetine and its interaction with rocuronium.
- Source :
-
Autonomic & autacoid pharmacology [Auton Autacoid Pharmacol] 2013 Apr; Vol. 33 (1-2), pp. 17-24. Date of Electronic Publication: 2013 Mar 06. - Publication Year :
- 2013
-
Abstract
- As selective serotonin reuptake inhibitors have an inhibitory effect on nicotinic acetylcholine receptors, they may affect the neuromuscular transmission and interact with neuromuscular blockers. This study was designed to observe the effect of fluoxetine on neuromuscular transmission and its interaction with rocuronium using the rat phrenic nerve hemidiaphragm and rabbit head drop methods. Rat phrenic nerve hemidiaphragms were mounted and stimulated using a train of four pulses (TOF). The effect of fluoxetine was studied on both indirectly and directly stimulated basal twitch responses by plotting cumulative dose response curves (DRCs). DRCs of rocuronium were obtained in the absence, and presence of 5 μm and 20 μm fluoxetine to study its interaction. ED5 , ED50 and ED95 values of rocuronium DRCs in absence and presence of fluoxetine were calculated. Fluoxetine significantly inhibited twitch responses in both indirect and directly stimulated preparations. Fluoxetine (20 μm) caused an increase in the potency of rocuronium such that the ED50 and ED95 values of rocuronium DRCs were significantly decreased. Partially inhibited twitch responses by fluoxetine (100 μm) were not reversed by neostigmine (3.3 μm) or 3,4 diaminopyridine (0.25 μm). Rabbits were given fluoxetine 0.25 mg kg(-1) and 1 mg kg(-1) orally for 15 days, and on 15th day, rocuronium infusion was given, and time for head drop was recorded. The time of head drop was significantly reduced in fluoxetine pretreated as compared to control group. Fluoxetine blocks the neuromuscular transmission and increases the potency of rocuronium-induced neuromuscular block.<br /> (© 2013 Blackwell Publishing Ltd.)
- Subjects :
- Animals
Diaphragm drug effects
Diaphragm innervation
Dose-Response Relationship, Drug
Drug Synergism
Electric Stimulation
Female
Male
Muscle Relaxation drug effects
Neuromuscular Junction physiology
Nicotinic Antagonists administration & dosage
Phrenic Nerve drug effects
Phrenic Nerve physiology
Rabbits
Rats
Rats, Wistar
Rocuronium
Synaptic Transmission drug effects
Androstanols administration & dosage
Fluoxetine administration & dosage
Neuromuscular Junction drug effects
Neuromuscular Nondepolarizing Agents administration & dosage
Selective Serotonin Reuptake Inhibitors administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1474-8673
- Volume :
- 33
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Autonomic & autacoid pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 23461555
- Full Text :
- https://doi.org/10.1111/aap.12005