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Rapid-antigen detection tests for group a streptococcal pharyngitis: revisiting false-positive results using polymerase chain reaction testing.
- Source :
-
The Journal of pediatrics [J Pediatr] 2013 Jun; Vol. 162 (6), pp. 1282-4, 1284.e1. Date of Electronic Publication: 2013 Mar 05. - Publication Year :
- 2013
-
Abstract
- We investigated mechanisms of the false-positive test results on rapid-antigen detection test (RADT) for group A Streptococcal (GAS) pharyngitis. Most RADT false-positives (76%) were associated with polymerase chain reaction-positive GAS results, suggesting that RADT specificity could be considered close to 100%. Finding that 61% of GAS culture-negative but RADT-positive cases were positive on both GAS polymerase chain reaction and Staphylococcus aureus testing, we posit bacterial inhibition as causative.<br /> (Copyright © 2013 Mosby, Inc. All rights reserved.)
- Subjects :
- Adolescent
Antigens, Bacterial genetics
Case-Control Studies
Child
Child, Preschool
False Positive Reactions
Humans
Pharyngitis microbiology
Polymerase Chain Reaction methods
Sensitivity and Specificity
Staphylococcus aureus immunology
Streptococcus pyogenes immunology
Antigens, Bacterial analysis
Pharyngitis diagnosis
Pharynx microbiology
Staphylococcus aureus isolation & purification
Streptococcal Infections diagnosis
Streptococcus pyogenes isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6833
- Volume :
- 162
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 23465407
- Full Text :
- https://doi.org/10.1016/j.jpeds.2013.01.050