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Experience of risk-reducing salpingo-oophorectomy for a BRCA1 mutation carrier and establishment of a system performing a preventive surgery for hereditary breast and ovarian cancer syndrome in Japan: our challenges for the future.
- Source :
-
Japanese journal of clinical oncology [Jpn J Clin Oncol] 2013 May; Vol. 43 (5), pp. 515-9. Date of Electronic Publication: 2013 Mar 13. - Publication Year :
- 2013
-
Abstract
- Background: Risk-reducing salpingo-oophorectomy is currently regarded as the most certain primary method for preventing ovarian cancer among BRCA1/2 mutation carriers with hereditary breast and ovarian cancer syndrome. However, risk-reducing salpingo-oophorectomy has rarely been performed in Japan.<br />Methods: We developed the first system in Japan for performing risk-reducing salpingo-oophorectomy for BRCA1/2 mutation carriers at our university hospital in 2008.<br />Results: The indication for risk-reducing salpingo-oophorectomy for patients with hereditary breast/ovarian cancer syndrome is currently limited in Japan. This situation may be because of the limited number of genetic counseling units, the limited number of facilities that can perform BRCA1/2 genetic testing and the fact that prophylactic surgery is not covered by health insurance in Japan.<br />Conclusions: Recent treatment guidelines for breast cancer in Japan recommended risk-reducing salpingo-oophorectomy for BRCA1/2 mutation carriers. Risk-reducing salpingo-oophorectomy should be performed in the framework of the standard therapeutic modality for BRCA1/2 mutation carriers in the near future.
- Subjects :
- Adult
Breast Neoplasms genetics
Female
Genetic Counseling
Genetic Predisposition to Disease
Genetic Testing
Hereditary Breast and Ovarian Cancer Syndrome genetics
Hereditary Breast and Ovarian Cancer Syndrome prevention & control
Humans
Insurance Coverage
Japan
Middle Aged
Ovarian Neoplasms genetics
Pedigree
Risk Factors
Risk Reduction Behavior
BRCA1 Protein genetics
BRCA2 Protein genetics
Breast Neoplasms prevention & control
Heterozygote
Mutation
Ovarian Neoplasms prevention & control
Ovariectomy economics
Salpingectomy economics
Subjects
Details
- Language :
- English
- ISSN :
- 1465-3621
- Volume :
- 43
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Japanese journal of clinical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 23487443
- Full Text :
- https://doi.org/10.1093/jjco/hyt036