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Role of SUV(max) obtained by 18F-FDG PET/CT in patients with a solitary pancreatic lesion: predicting malignant potential and proliferation.
- Source :
-
Nuclear medicine communications [Nucl Med Commun] 2013 Jun; Vol. 34 (6), pp. 533-9. - Publication Year :
- 2013
-
Abstract
- Objectives: Maximum standardized uptake value (SUV(max)) is a marker of tumor glucose metabolism detected by [(18)F]-fluorodeoxyglucose ((18)F-FDG) PET/computed tomography (PET/CT) and reflects tumor aggressiveness. The aim of the study was to evaluate the value of SUV(max) in differentiating benign from malignant solitary pancreatic lesions and explore the correlation between SUV(max) and tumor proliferative activity.<br />Materials and Methods: F-FDG PET/CT scans were performed in 80 patients with solitary pancreatic lesions who were scheduled for resective surgery. The relationships between SUV(max) and postoperative pathologic diagnosis, histologic grade, and Ki-67 proliferation index (PI) were analyzed.<br />Results: Of these 80 patients, 54 had malignant lesions. The SUV(max) of malignant tumors (6.3 ± 2.4) was significantly greater than that of benign lesions (2.9 ± 2.0) (P<0.001). Receiver-operating characteristic curve analysis showed that the SUV(max) cutoff value of 3.5 had a high sensitivity (92.6%) and specificity (76.9%) for the diagnosis of malignancies. Among pancreatic cancers with low (Ki-67<5%), moderate (5% ≤ Ki-67<50%), and high (Ki-67 ≥ 50%) PI, SUV(max) increased significantly from 4.2 ± 1.2, through 6.0 ± 1.7, to 8.6 ± 2.5 (P<0.001). The SUV(max) had a positive correlation with Ki-67 PI (P<0.001, r=0.60).<br />Conclusion: The SUV(max) of F-FDG PET/CT can be used in the differential diagnosis of solitary pancreatic lesions and can also aid in the prediction of proliferative activity of pancreatic cancer.
- Subjects :
- Adolescent
Adult
Aged
Cell Proliferation
Diagnosis, Differential
Female
Humans
Ki-67 Antigen metabolism
Male
Middle Aged
Pancreatic Neoplasms metabolism
Prognosis
Retrospective Studies
Young Adult
Fluorodeoxyglucose F18
Multimodal Imaging
Pancreatic Neoplasms diagnostic imaging
Pancreatic Neoplasms pathology
Positron-Emission Tomography
Tomography, X-Ray Computed
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5628
- Volume :
- 34
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Nuclear medicine communications
- Publication Type :
- Academic Journal
- Accession number :
- 23503000
- Full Text :
- https://doi.org/10.1097/MNM.0b013e328360668a