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Accelerated mice skin acute wound healing in vivo by combined treatment of argon and helium plasma needle.
- Source :
-
Archives of medical research [Arch Med Res] 2013 Apr; Vol. 44 (3), pp. 169-77. Date of Electronic Publication: 2013 Mar 16. - Publication Year :
- 2013
-
Abstract
- Background and Aims: The efficacy of a direct application of plasma needle to in vivo wound healing was experimentally studied in mice. This kind of plasma has achieved considerable success in blood coagulation and tissue restoration in mice. In the development of the present study, an argon plasma needle was chosen for coagulation purposes, whereas for healing purposes, a helium plasma needle was used.<br />Methods: Treatment was applied with a plasma needle produced by argon and helium to a wound induced in laboratory mice. Tissue regeneration was carried out by three argon plasma treatments with 0.5 SLPM flow for 1 min and three treatments of helium with 1.5 SLPM flow. Intervals between each treatment were 5 min and 60 min for argon and helium plasmas, respectively, thus completing a total treatment time of 180 min. Histological sections were performed to corroborate the internal bleeding and tissue regeneration.<br />Results: After three treatments with argon plasma, the blood produced in the wound was coagulated and protein material appeared. By means of treatment with helium plasma, an approach of the wound edges was produced until the conclusion thereof. These results were corroborated histologically.<br />Conclusions: This type of acceleration during the skin wound healing process can be attributed to the formation of reactive species such as NO, which were increased in the helium plasma needle with respect to the argon plasma needle.<br /> (Copyright © 2013 IMSS. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Acute Disease therapy
Animals
Argon administration & dosage
Argon therapeutic use
Helium administration & dosage
Helium therapeutic use
Mice
Nitric Oxide metabolism
Plasma Gases pharmacology
Skin Diseases therapy
Time Factors
Wound Healing physiology
Argon pharmacology
Helium pharmacology
Needles
Plasma Gases administration & dosage
Plasma Gases therapeutic use
Skin drug effects
Wound Healing drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1873-5487
- Volume :
- 44
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Archives of medical research
- Publication Type :
- Academic Journal
- Accession number :
- 23506720
- Full Text :
- https://doi.org/10.1016/j.arcmed.2013.02.001