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Anti-obesity effect of HT048, a herbal combination, in high fat diet-induced obese rats.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2012 Dec 11; Vol. 17 (12), pp. 14765-77. Date of Electronic Publication: 2012 Dec 11. - Publication Year :
- 2012
-
Abstract
- This study evaluated the anti-obesity effects of HT048, a combination of C. pinnatifida fruit and C. unshiu peel extracts, in high-fat diet (HFD)-induced obese rats. 4-Week-old male Sprague Dawley (SD) rats were divided into normal and high fat diet (HFD) groups. The HFD groups were further divided into five groups treated with distilled water, orlistat (40 mg/kg, twice daily, p.o) and HT048 (30, 100 and 300 mg/kg, twice daily, p.o.) for 12 weeks. Orlistat, an anti-obesity drug, was used as positive control in the HFD-induced obese rats. We measured the food intake, body weight, epididymal adipose tissue and liver weights, and serum total cholesterol (TC), triglyceride (TG), alanine transaminase (ALT), and aspartate aminotransferase (AST) levels. The body weight and epididymal adipose tissue and liver weights of the HT048 100 and 300 mg/kg treated groups were significantly lower than that of the HFD control group. Also, serum TC, TG, ALT, and AST levels in the HT048 100 and 300 mg/kg treated groups were significantly decreased. Moreover, the orlistat treated group showed significantly reduced body weight and improved serum lipoprotein, compared with the HFD control group. These results show that HT048 supplements improved obesity-related body weight and serum lipoprotein parameters in a HFD-induced obese rat model.
- Subjects :
- Adipose Tissue drug effects
Animals
Body Weight drug effects
Cholesterol blood
Crataegus chemistry
Dietary Fats administration & dosage
Drug Synergism
Fruit chemistry
Lactones pharmacology
Male
Orlistat
Rats
Rats, Sprague-Dawley
Triglycerides blood
Anti-Obesity Agents pharmacology
Diet, High-Fat
Obesity drug therapy
Phytotherapy
Plant Extracts pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 17
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 23519251
- Full Text :
- https://doi.org/10.3390/molecules171214765