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Hepatitis C-associated B-cell non-Hodgkin lymphomas. Epidemiology, molecular signature and clinical management.
- Source :
-
Journal of hepatology [J Hepatol] 2013 Jul; Vol. 59 (1), pp. 169-77. Date of Electronic Publication: 2013 Mar 27. - Publication Year :
- 2013
-
Abstract
- There is ample epidemiologic evidence for an association of chronic hepatitis C virus (HCV) infection with B-cell non-Hodgkin lymphoma (B-NHL). B-NHL subtypes most frequently associated with HCV are marginal zone lymphoma and diffuse large B-cell lymphoma. The most convincing evidence for a causal relationship between HCV infection and lymphoma development is the observation of B-NHL regression after HCV eradication by antiviral therapy (AVT). In fact, for indolent HCV-associated B-NHL, first-line AVT instead of standard immune-chemotherapy might be considered. Molecular mechanisms of HCV-NHL development are still poorly understood. Three general theories have emerged to understand the HCV-induced lymphomagenesis: (1) continuous external stimulation of lymphocyte receptors by viral antigens and consecutive proliferation; (2) HCV replication in B cells with oncogenic effect mediated by intracellular viral proteins; (3) permanent B-cell damage, e.g., mutation of tumor suppressor genes, caused by a transiently intracellular virus ("hit and run" theory). This review systematically summarizes the data on epidemiology, interventional studies, and molecular mechanisms of HCV-associated B-NHL.<br /> (Copyright © 2013 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Antineoplastic Agents therapeutic use
Antiviral Agents therapeutic use
B-Lymphocytes immunology
B-Lymphocytes virology
Hepacivirus immunology
Hepacivirus pathogenicity
Hepatitis C Antigens
Hepatitis C, Chronic drug therapy
Hepatitis C, Chronic epidemiology
Humans
Lymphoma, B-Cell drug therapy
Lymphoma, B-Cell epidemiology
Models, Biological
Risk Factors
Hepatitis C, Chronic complications
Lymphoma, B-Cell etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0641
- Volume :
- 59
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 23542089
- Full Text :
- https://doi.org/10.1016/j.jhep.2013.03.018