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[Characteristic of the complement system in patients with ischemic heart disease with moderate and marked hemolysis after operations with cardiopulmonary bypass].
- Source :
-
Kardiologiia [Kardiologiia] 2013; Vol. 53 (2), pp. 4-9. - Publication Year :
- 2013
-
Abstract
- A study of the complement system in cardiosurgical patients with moderate (40 patients) and marked (18 patients) hemolysis after coronary artery bypass grafting in conditions of cardiopulmonary bypass was carried out. Before and after operation the content of D35+-, D55+-erythrocytes and reticulocytes in blood, free hemoglobin in blood plasma, indicators of the functional state of classical, lectin and alternative pathways of complement activation as well as concentration of its terminal complex in blood serum were analyzed. It was established that development of marked hemolysis was associated with higher (compared with moderate hemolysis) content of terminal complement complex and reticulocytes in blood before operation as well as deficiency of D55+- erythrocytes and low activity of alternative pathway.
- Subjects :
- CD55 Antigens metabolism
Coronary Artery Bypass methods
Female
Hemoglobinometry
Humans
Male
Middle Aged
Receptors, Complement 3b metabolism
Reticulocyte Count
Severity of Illness Index
Cardiopulmonary Bypass adverse effects
Cardiopulmonary Bypass methods
Complement Membrane Attack Complex analysis
Complement Membrane Attack Complex metabolism
Complement Pathway, Alternative
Erythrocytes immunology
Hemolysis immunology
Myocardial Ischemia blood
Myocardial Ischemia surgery
Subjects
Details
- Language :
- Russian
- ISSN :
- 0022-9040
- Volume :
- 53
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Kardiologiia
- Publication Type :
- Academic Journal
- Accession number :
- 23548384