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lnterleukin-8 gene polymorphism and susceptibility to gastric cancer in a Brazilian population.
- Source :
-
Biological research [Biol Res] 2012; Vol. 45 (4), pp. 369-74. - Publication Year :
- 2012
-
Abstract
- Background: Studies have demonstrated that some polymorphisms in different interleukin genes may increase the risk of cancer. The aim of this study was to investigate the association between the IL-8 (rs4073) -251A/T gene polymorphism and the risk of gastric cancer (GC).<br />Patients and Methods: A case-control study was conducted on patients with noncardia gastric cancer. DNA was extracted from leukocytes and the IL-8 (rs4073) -251A/T polymorphism was analyzed by PCR-RFLP. Infection with Helicobacter pylori was investigated in the serum by ELISA.<br />Results: The sample consisted of 104 patients with GC and 196 controls. Cigarette smoking (P=0.007) and high fat intake (P=0.01) were more frequent in patients with GC. The proportion of patients infected with H. pylori was similar in the two groups (P=0.101). The frequency of the genotype A/T was higher in the cancer group (P=0.008). An increased risk of GC was found in subjects carrying the genotype A/T (OR=2.50, CI: 1.27-4.90), subjects with high fat intake (OR=1.92, CI: 1.17-3.15), and smokers (OR=2.00, CI: 1.203.31).<br />Conclusions: Subjects with the heterozygous A/T genotype, high fat intake and smokers or ex-smokers presented an increased risk of GC. Individuals with A/A genotype may have protective effect for GC.
- Subjects :
- Brazil
Case-Control Studies
Female
Genotype
Helicobacter Infections complications
Helicobacter pylori immunology
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Risk Factors
Stomach Neoplasms microbiology
Genetic Predisposition to Disease
Interleukin-8 genetics
Polymorphism, Genetic
Stomach Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0717-6287
- Volume :
- 45
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Biological research
- Publication Type :
- Academic Journal
- Accession number :
- 23558993
- Full Text :
- https://doi.org/10.4067/S0716-97602012000400007