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Synthesis and reactivity of unsymmetrical azomethine imines formed using alkene aminocarbonylation.
- Source :
-
Organic letters [Org Lett] 2013 Apr 19; Vol. 15 (8), pp. 1890-3. Date of Electronic Publication: 2013 Apr 08. - Publication Year :
- 2013
-
Abstract
- Complex cyclic azomethine imines possessing a β-aminocarbonyl motif can be accessed readily from simple alkenes and hydrazones. This alkene aminocarbonylation approach allows formation of ketone-derived azomethine imines of unprecedented complexity. Since unsymmetrical hydrazones are used, two stereoisomers are formed: the reactivity of chiral derivatives is explored in both intra- and intermolecular systems.
- Subjects :
- Azo Compounds chemistry
Catalysis
Combinatorial Chemistry Techniques
Cyclization
Imines chemistry
Ketones chemical synthesis
Ketones chemistry
Molecular Structure
Stereoisomerism
Thiosemicarbazones chemistry
Alkenes chemistry
Azo Compounds chemical synthesis
Hydrazones chemistry
Imines chemical synthesis
Thiosemicarbazones chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 15
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 23565796
- Full Text :
- https://doi.org/10.1021/ol400542b