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4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 May 15; Vol. 23 (10), pp. 3001-6. Date of Electronic Publication: 2013 Mar 21. - Publication Year :
- 2013
-
Abstract
- Isoxazoline insecticides have been shown to be potent blockers of insect GABA receptors with excellent activity on a broad pest range, including Lepidoptera and Hemiptera. Herein we report on the synthesis, biological activity and mode-of-action for a class of 4-heterocyclic aryl isoxazoline insecticides.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Chloride Channels metabolism
Dose-Response Relationship, Drug
Insecta
Insecticides chemical synthesis
Insecticides chemistry
Isoxazoles chemical synthesis
Isoxazoles chemistry
Molecular Structure
Structure-Activity Relationship
Chloride Channels antagonists & inhibitors
Insecticides pharmacology
Isoxazoles pharmacology
Receptors, GABA metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 23
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 23566518
- Full Text :
- https://doi.org/10.1016/j.bmcl.2013.03.031