Perspective on fever: the basic science and conventional medicine.

Authors :: Cannon JG
Source :: Complementary therapies in medicine [Complement Ther Med] 2013 Apr; Vol. 21 Suppl 1, pp. S54-60. Date of Electronic Publication: 2011 Sep 17.
Publication Year :: 2013
Abstract: This review describes how fever is generated as a regulated increase in body temperature. It results from an upward shift in the thermoregulatory set point, mediated by pyrogenic cytokines released from monocytes/macrophages in response to infection or trauma. Evidence will be presented that fever is part of an integrated host defense system, and that failure to generate a fever in response to infection is generally associated with a poorer prognosis.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)