A new synthesis of 4'-resveratrol esters and evaluation of the potential for anti-depressant activity.

Authors :: Acerson MJ
Fabick KM
Wong Y
Blake C
Lephart ED
Andrus MB
Source :: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 May 15; Vol. 23 (10), pp. 2941-4. Date of Electronic Publication: 2013 Mar 21.
Publication Year :: 2013
Abstract: The 4'-ester analog of the disease preventative resveratrol 1 (RV), 4'-acetyl-RV 2 along with 4'-pivaloate 13 and benzoate 14 RV were synthesized. The previously developed palladium catalyzed decarbonylative Heck coupling was used to assemble the stilbene core together with 3,5-dibenzyl protected phenol intermediates that allowed for efficient coupling and deprotection using boron trifluoride etherate. Studies with Long-Evans rats were performed to establish safety, toxicity, and behavioral parameters. In addition, the Porsalt forced-swim test was used to demonstrate anti-depressant activity.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)

Subjects :: Animals
Antidepressive Agents chemical synthesis
Antidepressive Agents chemistry
Dose-Response Relationship, Drug
Esters chemical synthesis
Esters chemistry
Female
Molecular Structure
Rats
Rats, Long-Evans
Stilbenes chemical synthesis
Stilbenes chemistry
Antidepressive Agents pharmacology
Behavior, Animal drug effects
Depression drug therapy
Esters pharmacology
Stilbenes pharmacology
Swimming

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