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Sleep disordered breathing in a cohort of patients with sporadic inclusion body myositis.

Sleep disordered breathing in a cohort of patients with sporadic inclusion body myositis.

Authors :
Della Marca G
Sancricca C
Losurdo A
Di Blasi C
De Fino C
Morosetti R
Broccolini A
Testani E
Scarano E
Servidei S
Mirabella M
Source :
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [Clin Neurophysiol] 2013 Aug; Vol. 124 (8), pp. 1615-21. Date of Electronic Publication: 2013 Apr 11.
Publication Year :
2013

Abstract

Objective: The aims of the study were: (1) to evaluate subjective sleep quality and daytime sleepiness in patients affected by sporadic inclusion-body myositis (IBM); (2) to define the sleep and sleep-related respiratory pattern in IBM patients.<br />Methods: Thirteen consecutive adult patients affected by definite IBM were enrolled, six women and seven men, mean age 66.2 ± 11.1 years (range: 50-80). Diagnosis was based on clinical and muscle biopsy studies. All patients underwent subjective sleep evaluation (Pittsburgh Sleep Quality Index, PSQI and Epworth Sleepiness Scale, ESS), oro-pharingo-esophageal scintigraphy, pulmonary function tests, psychometric measures, anatomic evaluation of upper airways, and laboratory-based polysomnography. Findings in IBM patients were compared to those obtained from a control group of 25 healthy subjects (13 men and 12 women, mean age 61.9 ± 8.6 years).<br />Results: Disease duration was >10 years in all. Mean IBM severity score was 28.8 ± 5.4 (range 18-36). Dysphagia was present in 10 patients. Nine patients had PSQI scores ≥ 5; patients had higher mean PSQI score (IBM: 7.2 ± 4.7, CONTROLS: 2.76 ± 1.45, p=0.005); one patient (and no controls) had EES>9. Polysomnography showed that IBM patients, compared to controls, had lower sleep efficiency (IBM: 78.8 ± 12.0%,<br />Controls: 94.0 ± 4.5%, p<0.001), more awakenings (IBM: 11.9 ± 11.0, CONTROLS: 5.2 ± 7.5, p=0.009) and increased nocturnal time awake (IBM: 121.2 ± 82.0 min.,<br />Controls: 46.12 ± 28.8 min., p=0.001). Seven Patients (and no controls) had polysomnographic findings consistent with sleep disordered breathing (SDB).<br />Conclusion: Data suggest that sleep disruption, and in particular SDB, might be highly prevalent in IBM.<br />Significance: Data indicate that IBM patients have poor sleep and high prevalence of SDB.<br /> (Copyright © 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1872-8952
Volume :
124
Issue :
8
Database :
MEDLINE
Journal :
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Publication Type :
Academic Journal
Accession number :
23583020
Full Text :
https://doi.org/10.1016/j.clinph.2013.03.002