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Sacrococcygeal yolk sac tumor developing after teratoma: a clinicopathological study of pediatric sacrococcygeal germ cell tumors and a proposal of the pathogenesis of sacrococcygeal yolk sac tumors.
Sacrococcygeal yolk sac tumor developing after teratoma: a clinicopathological study of pediatric sacrococcygeal germ cell tumors and a proposal of the pathogenesis of sacrococcygeal yolk sac tumors.
- Source :
-
Journal of pediatric surgery [J Pediatr Surg] 2013 Apr; Vol. 48 (4), pp. 776-81. - Publication Year :
- 2013
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Abstract
- Purpose: We evaluated the clinicopathological characteristics of pediatric sacrococcygeal germ cell tumors (SGCTs) and yolk sac tumors (YSTs) developing after sacrococcygeal teratoma (SCT) resection, and discussed the pathogenesis of sacrococcygeal YST.<br />Methods: We retrospectively analyzed pediatric SGCT patients attending 10 Japanese institutions.<br />Results: A total of 289 patients were eligible, of which 74.6% were girls. The mean age at surgery was 7.1months. There were 194 mature and 47 immature teratomas, and 48 YSTs. YST developed after SCT resection in 13 patients (5.4% of SCTs), and was detected between 5 and 30months after resection. At initial surgery, 9 of these 13 patients were neonates, 12 underwent gross complete resection with coccygectomy, and 9 had histologically mature teratoma without microscopic YST foci. Postoperative serum alpha-fetoprotein (AFP) levels were regularly examined in 11 patients. Intervals of AFP measurement≤4months helped to detect subclinical localized YSTs for resection.<br />Conclusions: The characteristics of SGCT in Japanese children were similar with those reported in Europe or the United States. YST developed after SCT resection not only in patients with previously reported risk factors. We recommend that patients undergo serum AFP monitoring every 3months for≥3years after SCT resection.<br /> (Copyright © 2013 Elsevier Inc. All rights reserved.)
- Subjects :
- Combined Modality Therapy
Endodermal Sinus Tumor drug therapy
Female
Humans
Infant
Infant, Newborn
Japan
Male
Retrospective Studies
Teratoma drug therapy
Treatment Outcome
alpha-Fetoproteins analysis
Endodermal Sinus Tumor pathology
Endodermal Sinus Tumor surgery
Sacrococcygeal Region pathology
Sacrococcygeal Region surgery
Teratoma pathology
Teratoma surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1531-5037
- Volume :
- 48
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of pediatric surgery
- Publication Type :
- Academic Journal
- Accession number :
- 23583133
- Full Text :
- https://doi.org/10.1016/j.jpedsurg.2012.08.028