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A label-free, quantitative assay of amyloid fibril growth based on intrinsic fluorescence.
- Source :
-
Chembiochem : a European journal of chemical biology [Chembiochem] 2013 May 10; Vol. 14 (7), pp. 846-50. Date of Electronic Publication: 2013 Apr 16. - Publication Year :
- 2013
-
Abstract
- Kinetic assay of seeded growth: The graph shows the variation in intrinsic fluorescence intensity of amyloid fibrils. Fluorescence increases during the seeded aggregation of α-synuclein seeds with α-synuclein monomeric protein (blue curve) but not when α-synuclein seeds are incubated with β-synuclein monomeric protein (black curve), thus showing that no seeded growth occurred in this case.<br /> (© 2013 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Attribution Non-Commercial NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.)
Details
- Language :
- English
- ISSN :
- 1439-7633
- Volume :
- 14
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Chembiochem : a European journal of chemical biology
- Publication Type :
- Academic Journal
- Accession number :
- 23592254
- Full Text :
- https://doi.org/10.1002/cbic.201300103