Antibody-functionalized magnetic polymersomes: in vivo targeting and imaging of bone metastases using high resolution MRI.

Authors :: Pourtau L
Oliveira H
Thevenot J
Wan Y
Brisson AR
Sandre O
Miraux S
Thiaudiere E
Lecommandoux S
Source :: Advanced healthcare materials [Adv Healthc Mater] 2013 Nov; Vol. 2 (11), pp. 1420-4. Date of Electronic Publication: 2013 Apr 19.
Publication Year :: 2013
Abstract: Multifunctional polymersomes loaded with maghemite nanoparticles and grafted with an antibody, directed against human endothelial receptor 2, are developed as novel MRI contrast agents for bone metastasis imaging. Upon administration in mice bearing bone tumor grown from human breast cancer cells, MR images show targeting and enhanced retention of antibody-labeled polymersomes at the tumor site.<br /> (Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Animals
Cell Line, Tumor
Ferric Compounds chemistry
Humans
Mice
Nanoparticles chemistry
Tissue Distribution
Antibodies metabolism
Bone Neoplasms diagnosis
Bone Neoplasms secondary
Magnetic Phenomena
Magnetic Resonance Imaging methods
Polymers chemistry

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