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Antibody-functionalized magnetic polymersomes: in vivo targeting and imaging of bone metastases using high resolution MRI.
- Source :
-
Advanced healthcare materials [Adv Healthc Mater] 2013 Nov; Vol. 2 (11), pp. 1420-4. Date of Electronic Publication: 2013 Apr 19. - Publication Year :
- 2013
-
Abstract
- Multifunctional polymersomes loaded with maghemite nanoparticles and grafted with an antibody, directed against human endothelial receptor 2, are developed as novel MRI contrast agents for bone metastasis imaging. Upon administration in mice bearing bone tumor grown from human breast cancer cells, MR images show targeting and enhanced retention of antibody-labeled polymersomes at the tumor site.<br /> (Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Details
- Language :
- English
- ISSN :
- 2192-2659
- Volume :
- 2
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Advanced healthcare materials
- Publication Type :
- Academic Journal
- Accession number :
- 23606565
- Full Text :
- https://doi.org/10.1002/adhm.201300061