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Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasme.
- Source :
-
Journal of natural products [J Nat Prod] 2013 May 24; Vol. 76 (5), pp. 852-7. Date of Electronic Publication: 2013 Apr 23. - Publication Year :
- 2013
-
Abstract
- Five novel tigliane-type diterpenes, stelleracins A-E (3-7), a novel flavanone dimer, chamaeflavone A (8), and six known compounds were isolated from the roots of Stellera chamaejasme. Their structures were elucidated by extensive spectroscopic analyses. The isolated compounds were evaluated for anti-HIV activity in MT4 cells. New compounds 3-5 showed potent anti-HIV activity (EC90 0.00056-0.0068 μM) and relatively low or no cytotoxicity (IC50 4.4-17.2 μM). These new compounds represent promising new leads for development into anti-AIDS clinical trial candidates.
- Subjects :
- Acquired Immunodeficiency Syndrome drug therapy
Anti-HIV Agents chemistry
Cell Survival drug effects
Diterpenes chemistry
Flavanones chemistry
Molecular Structure
Nepal
Nuclear Magnetic Resonance, Biomolecular
Plant Roots chemistry
Anti-HIV Agents isolation & purification
Anti-HIV Agents pharmacology
Diterpenes isolation & purification
Diterpenes pharmacology
Flavanones isolation & purification
Flavanones pharmacology
Thymelaeaceae chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6025
- Volume :
- 76
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 23611151
- Full Text :
- https://doi.org/10.1021/np300815t