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Human papillomavirus 16 detected in nasopharyngeal carcinomas in white Americans but not in endemic Southern Chinese patients.
- Source :
-
Head & neck [Head Neck] 2014 May; Vol. 36 (5), pp. 709-14. Date of Electronic Publication: 2013 Oct 26. - Publication Year :
- 2014
-
Abstract
- Background: We evaluated the relationship of human papillomavirus (HPV) and Epstein-Barr virus (EBV) with race in endemic and nonendemic cohorts of patients with nasopharyngeal carcinoma (NPC), and with smoking status in the nonendemic cohort.<br />Methods: Tissue microarrays (TMAs) were constructed using samples from 86 patients treated in southern China and 108 patients from Stanford, California. TMAs were stained with p16, HPV in situ hybridization (ISH), and EBV ISH. Polymerase chain reaction (PCR) was used to confirm EBV(-) cases and HPV status in p16(+) cases. Survival data was available for the Stanford cohort only.<br />Results: No HPV(+) cases were detected in the Chinese cohort. In the Stanford cohort, 5 of 11 EBV(-) cases harbored HPV-16, 10 of 10 occurred in whites, and 8 of 11 were smokers. Patients with EBV(-) NPC also showed a trend toward worse survival.<br />Conclusion: EBV(-) NPC shows an association with the presence of HPV, white race, and smoking. In contrast, EBV(-) NPC shows no association with HPV in the endemic cohort.<br /> (Copyright © 2013 Wiley Periodicals, Inc.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Asian People statistics & numerical data
Biopsy, Needle
Chi-Square Distribution
China epidemiology
Cohort Studies
DNA, Viral analysis
Endemic Diseases
Female
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Male
Middle Aged
Nasopharyngeal Neoplasms pathology
Polymerase Chain Reaction methods
Retrospective Studies
Survival Analysis
United States epidemiology
White People statistics & numerical data
Young Adult
Herpesvirus 4, Human isolation & purification
Human papillomavirus 16 isolation & purification
Nasopharyngeal Neoplasms epidemiology
Nasopharyngeal Neoplasms virology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0347
- Volume :
- 36
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Head & neck
- Publication Type :
- Academic Journal
- Accession number :
- 23616441
- Full Text :
- https://doi.org/10.1002/hed.23362