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Shortened blood coagulation times in genetically obese rats and diet-induced obese mice.
- Source :
-
The Journal of veterinary medical science [J Vet Med Sci] 2013; Vol. 75 (9), pp. 1245-8. Date of Electronic Publication: 2013 Apr 26. - Publication Year :
- 2013
-
Abstract
- The aim of this study was to investigate blood coagulation times in genetically obese rats and diet-induced obese (DIO) mice in order to clarify the relationship between visceral obesity and blood coagulation. WBN/Kob-Lepr(fa) (fa/fa) rats, a genetically obese model, exhibited a significantly shorter activated partial thromboplastin time (aPTT) and prothrombin time (PT) than age-matched Wistar rats. C57BL/6J mice fed a high-fat diet (60%), a DIO model, exhibited significantly shorter aPTT, PT and thrombin time than lean mice fed a standard diet. Higher body weight, visceral fat weight and insulin resistance were also shared by fa/fa rats and DIO mice. These results suggest that visceral obesity is related to accelerated blood coagulation in addition to disrupted metabolism of glucose and lipids.
Details
- Language :
- English
- ISSN :
- 1347-7439
- Volume :
- 75
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- The Journal of veterinary medical science
- Publication Type :
- Academic Journal
- Accession number :
- 23628972
- Full Text :
- https://doi.org/10.1292/jvms.13-0029