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[The antiaggregant action of 2-morpholino-5-(thienyl-2)-6-H-1,3,4-thiadiazine in in vitro and ex vivo experiments].

Authors :
Logvinova IuS
Makarov VA
Chupakhin ON
Sidorova LP
Perova NM
Rusinov VL
Source :
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2013; Vol. 76 (2), pp. 13-6.
Publication Year :
2013

Abstract

The influence of 2-morpholino-5-(thienyl-2)-6-H-1,3,4-thiadiazine (H-29) on the platelet aggregation has been studied in experiments on donor plasma in vitro. It is established that H-29 causes a decrease in the platelet interaction induced by ADP and arachidonic acid. The influence of H-29 on platelet aggregation was also studied in ex vivo experiments with intravenous and oral administration, and some parameters of plasmatic hemostasis were evaluated.

Details

Language :
Russian
ISSN :
0869-2092
Volume :
76
Issue :
2
Database :
MEDLINE
Journal :
Eksperimental'naia i klinicheskaia farmakologiia
Publication Type :
Academic Journal
Accession number :
23631277