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[The antiaggregant action of 2-morpholino-5-(thienyl-2)-6-H-1,3,4-thiadiazine in in vitro and ex vivo experiments].
- Source :
-
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2013; Vol. 76 (2), pp. 13-6. - Publication Year :
- 2013
-
Abstract
- The influence of 2-morpholino-5-(thienyl-2)-6-H-1,3,4-thiadiazine (H-29) on the platelet aggregation has been studied in experiments on donor plasma in vitro. It is established that H-29 causes a decrease in the platelet interaction induced by ADP and arachidonic acid. The influence of H-29 on platelet aggregation was also studied in ex vivo experiments with intravenous and oral administration, and some parameters of plasmatic hemostasis were evaluated.
- Subjects :
- Adenosine Diphosphate pharmacology
Animals
Arachidonic Acid pharmacology
Blood Coagulation Tests
Blood Platelets cytology
Humans
Morpholines chemical synthesis
Platelet Aggregation Inhibitors chemical synthesis
Platelet Count
Rabbits
Thiadiazines chemical synthesis
Blood Coagulation drug effects
Blood Platelets drug effects
Morpholines pharmacology
Platelet Aggregation drug effects
Platelet Aggregation Inhibitors pharmacology
Thiadiazines pharmacology
Subjects
Details
- Language :
- Russian
- ISSN :
- 0869-2092
- Volume :
- 76
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Eksperimental'naia i klinicheskaia farmakologiia
- Publication Type :
- Academic Journal
- Accession number :
- 23631277