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[Pulmonary expression levels of fibroblast growth factor receptors and lung fibrosis in mice at different ages].
- Source :
-
Nan fang yi ke da xue xue bao = Journal of Southern Medical University [Nan Fang Yi Ke Da Xue Xue Bao] 2013 Apr; Vol. 33 (4), pp. 607-10. - Publication Year :
- 2013
-
Abstract
- Objective: To explore the correlation of pulmonary expressions of fibroblast growth factor receptors (FGFR1-4) with lung fibrosis and aging.<br />Methods: Real-time fluorescence quantitative PCR was used to detect the expression levels of FGFR1-4 in the lung tissues, and lung fibrosis was observed by HE and Masson staining in mice at different ages.<br />Results: The 4 subtypes of FGFR showed different expression levels in the lung tissues of mice, and FGFR2 had the highest expressions. The expression levels of all the 4 FGFR subtypes in 8-month-old mice were significantly lower than those in 5-week-old mice. The 8-month-old mice tended to present with histological changes of lung fibrosis.<br />Conclusion: FGFR expressions is down-regulated with aging in mice. Among the FGFR subtypes, FGFR2 is expressed at the highest level. The occurrence of lung fibrosis with aging is probably associated with down-regulated FGFR expression. FGF/FGFR signaling may participate in the aging process and regulation of lung fibrosis.
- Subjects :
- Animals
Lung pathology
Male
Mice
Mice, Inbred C57BL
Pulmonary Fibrosis pathology
Pulmonary Fibrosis physiopathology
Receptors, Fibroblast Growth Factor classification
Signal Transduction
Aging physiology
Lung metabolism
Pulmonary Fibrosis metabolism
Receptors, Fibroblast Growth Factor metabolism
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1673-4254
- Volume :
- 33
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Nan fang yi ke da xue xue bao = Journal of Southern Medical University
- Publication Type :
- Academic Journal
- Accession number :
- 23644131