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Population genomics of post-vaccine changes in pneumococcal epidemiology.
- Source :
-
Nature genetics [Nat Genet] 2013 Jun; Vol. 45 (6), pp. 656-63. Date of Electronic Publication: 2013 May 05. - Publication Year :
- 2013
-
Abstract
- Whole-genome sequencing of 616 asymptomatically carried Streptococcus pneumoniae isolates was used to study the impact of the 7-valent pneumococcal conjugate vaccine. Comparison of closely related isolates showed the role of transformation in facilitating capsule switching to non-vaccine serotypes and the emergence of drug resistance. However, such recombination was found to occur at significantly different rates across the species, and the evolution of the population was primarily driven by changes in the frequency of distinct genotypes extant before the introduction of the vaccine. These alterations resulted in little overall effect on accessory genome composition at the population level, contrasting with the decrease in pneumococcal disease rates after the vaccine's introduction.
- Subjects :
- Child
Drug Resistance, Bacterial genetics
Gene Frequency
Genetic Variation
Genome, Bacterial
Genotype
Humans
Mass Vaccination
Metagenomics
Models, Genetic
Multigene Family
Phylogeny
Pneumococcal Infections epidemiology
Pneumococcal Infections microbiology
Pneumococcal Vaccines
Prevalence
Streptococcus pneumoniae immunology
United States epidemiology
Pneumococcal Infections prevention & control
Streptococcus pneumoniae genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1546-1718
- Volume :
- 45
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Academic Journal
- Accession number :
- 23644493
- Full Text :
- https://doi.org/10.1038/ng.2625