Back to Search
Start Over
Acute insulin resistance assessed by the homeostatic model assessment in acute coronary syndromes without previously known diabetes.
- Source :
-
Angiology [Angiology] 2014 Jul; Vol. 65 (6), pp. 519-24. Date of Electronic Publication: 2013 May 06. - Publication Year :
- 2014
-
Abstract
- We assessed the incidence and the prognostic role for early death of acute insulin resistance (by means of homeostatic model assessment [HOMA] index) in 1350 patients with acute coronary syndrome (ACS) consecutively admitted to our intensive cardiac care unit (ICCU). The incidence of HOMA positivity was 5% (68 of 1350), with the highest percentage of HOMA positivity among ST-segment elevation myocardial infarction (STEMI). Patients with HOMA positivity showed a higher body mass index (P = .003), lower values of admission and discharge left-ventricular ejection fraction (LVEF; P < .001 and P = .003, respectively), and higher levels of peak troponin I (Tn I; P < .001). The HOMA index was an independent predictor of early death (odds ratio 1.724, 95% confidence interval 1.252-2.375, P = .001). In patients with ACS and without previously known diabetes, acute insulin resistance (HOMA index) is associated with a larger myocardial damage (ie, higher values of peak Tn I and lower LVEF) and a greater inflammatory activation (indicated by correlation with leukocyte count). The HOMA positivity was an independent predictor of in-ICCU mortality.<br /> (© The Author(s) 2013.)
- Subjects :
- Acute Coronary Syndrome therapy
Aged
Aged, 80 and over
Body Mass Index
Female
Homeostasis
Humans
Intensive Care Units
Italy epidemiology
Leukocyte Count
Logistic Models
Male
Middle Aged
Prognosis
Stroke Volume
Troponin I blood
Acute Coronary Syndrome mortality
Hospital Mortality
Insulin Resistance
Subjects
Details
- Language :
- English
- ISSN :
- 1940-1574
- Volume :
- 65
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Angiology
- Publication Type :
- Academic Journal
- Accession number :
- 23650645
- Full Text :
- https://doi.org/10.1177/0003319713489018