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Fluctuation of serum C3 levels reflects disease activity and metabolic background in patients with IgA nephropathy.
- Source :
-
Journal of nephrology [J Nephrol] 2013 Jul-Aug; Vol. 26 (4), pp. 708-15. Date of Electronic Publication: 2013 May 06. - Publication Year :
- 2013
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Abstract
- Background: We focused on the fluctuations of serum C3 levels throughout the clinical course of patients and investigated the relationship between these fluctuations and clinical findings.<br />Methods: IgA nephropathy patients (n = 122) were enrolled in the present study. Serum C3 and other clinical markers were compared at the time of renal biopsy and at last follow-up (6.67 ± 2.07 years). Patients were divided into 3 groups based on serum C3 levels: Group I with first C3 levels below the mean -1 SD, which turned into an increase at last observation; group II with first C3 levels more than the mean +1 SD, which turned into a decrease at last observation; and group III, with first C3 levels more than the mean +1 SD, which turned into an increase at last observation. First and last levels of clinical markers were compared among the 3 groups.<br />Results: Serum C3 levels of the patients whose renal symptoms, including hematuria, proteinuria and estimated glomerular filtration rate (eGFR), were improved, were significantly increased at last observation (p<0.05, p<0.01, p<0.01, respectively). Age, total cholesterol and triglyceride levels in group III were significantly higher than those in group I. Group II showed a significant reduction of urinary protein. Groups I and II maintained renal function, but group III showed a significant deterioration of renal function.<br />Conclusions: The levels and fluctuations of serum C3 might reflect the disease activity and metabolic alteration in patients with IgA nephropathy.
Details
- Language :
- English
- ISSN :
- 1724-6059
- Volume :
- 26
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 23661588
- Full Text :
- https://doi.org/10.5301/jn.5000278