Dissemination of the KPC-2 carbapenemase in non-Klebsiella pneumoniae enterobacterial isolates from Colombia.

Authors :: Cuzon G
Naas T
Correa A
Quinn JP
Villegas MV
Nordmann P
Source :: International journal of antimicrobial agents [Int J Antimicrob Agents] 2013 Jul; Vol. 42 (1), pp. 59-62. Date of Electronic Publication: 2013 May 09.
Publication Year :: 2013
Abstract: Klebsiella pneumoniae carbapenemase (KPC)-type enzymes have largely disseminated worldwide among K. pneumoniae isolates. In this study, 11 non-K. pneumoniae KPC-producing enterobacterial isolates from four hospitals located in different Colombian cities were genetically investigated. All isolates were multidrug-resistant and harboured the bla(KPC-2) gene along with several other acquired β-lactamase genes. The bla(KPC-2) gene was associated with transposon Tn4401b inserted in different loci of plasmids varying in size and replicon type. The presence of KPC-2 in different enterobacterial species from different cities within Colombia underlines the spread of KPC beyond K. pneumoniae.<br /> (Copyright © 2013 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.)

Subjects :: Colombia epidemiology
DNA Transposable Elements
Drug Resistance, Multiple, Bacterial
Enterobacteriaceae drug effects
Enterobacteriaceae isolation & purification
Enterobacteriaceae Infections microbiology
Genetic Loci
Hospitals
Humans
Molecular Epidemiology
Prevalence
Enterobacteriaceae enzymology
Enterobacteriaceae Infections epidemiology
beta-Lactamases genetics

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