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TALEN-mediated editing of the mouse Y chromosome.
- Source :
-
Nature biotechnology [Nat Biotechnol] 2013 Jun; Vol. 31 (6), pp. 530-2. Date of Electronic Publication: 2013 May 12. - Publication Year :
- 2013
-
Abstract
- The functional study of Y chromosome genes has been hindered by a lack of mouse models with specific Y chromosome mutations. We used transcription activator-like effector nuclease (TALEN)-mediated gene editing in mouse embryonic stem cells (mESCs) to produce mice with targeted gene disruptions and insertions in two Y-linked genes--Sry and Uty. TALEN-mediated gene editing is a useful tool for dissecting the biology of the Y chromosome.
Details
- Language :
- English
- ISSN :
- 1546-1696
- Volume :
- 31
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Nature biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 23666012
- Full Text :
- https://doi.org/10.1038/nbt.2595