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New azole antagonists with high affinity for the P2Y(1) receptor.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Jun 15; Vol. 23 (12), pp. 3519-22. Date of Electronic Publication: 2013 Apr 25. - Publication Year :
- 2013
-
Abstract
- Five-membered-ring heterocyclic urea mimics have been found to be potent and selective antagonists of the P2Y1 receptor. SAR of the various heterocyclic replacements is presented, as well as side-chain SAR of the more potent thiadiazole ring system which leads to thiadiazole 4c as a new antiplatelet agent.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Subjects :
- Biomimetic Materials chemistry
Biomimetic Materials pharmacology
Humans
Kinetics
Protein Binding
Structure-Activity Relationship
Urea chemistry
Purinergic P2Y Receptor Antagonists chemistry
Purinergic P2Y Receptor Antagonists pharmacology
Receptors, Purinergic P2Y1 chemistry
Thiadiazoles chemistry
Thiadiazoles pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 23
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Editorial & Opinion
- Accession number :
- 23668989
- Full Text :
- https://doi.org/10.1016/j.bmcl.2013.04.041