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Inhibition of proliferation of cervical and leukemic cancer cells by penicillin G.
- Source :
-
Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2013; Vol. 14 (3), pp. 2127-30. - Publication Year :
- 2013
-
Abstract
- Cancer, despite all the efforts, still causes one in five deaths worldwide. Surgery, chemotherapy and radiotherapy provide inadequate protection and instead affect normal cells along with cancer cells. The search for cancer cures from natural products (plants and animals) has been practice for over a decade and the use of purified chemical to treat cancer still continues. Several studies have been undertaken during last three decades to find the anti-cancerous property of various plant extract and toxins secreted by animals and micro-organism. These lead to the discovery of several promising molecule having anticancer activity, some of which are in clinical trial and may emerged to be a potential future drug in cancer therapy. In this study we have used penicillin to evaluate its anti-cancer activity. It shown significant effects at cellular and molecular levels against growth of HeLa and K562 cell lines.
- Subjects :
- Animals
Biomarkers, Tumor genetics
Blotting, Western
Cells, Cultured
Chlorocebus aethiops
Female
Humans
Leukemia drug therapy
Leukemia genetics
RNA, Messenger genetics
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
Uterine Cervical Neoplasms drug therapy
Uterine Cervical Neoplasms genetics
Vero Cells
Anti-Bacterial Agents pharmacology
Cell Proliferation drug effects
Leukemia pathology
Penicillin G pharmacology
Uterine Cervical Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 2476-762X
- Volume :
- 14
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Asian Pacific journal of cancer prevention : APJCP
- Publication Type :
- Academic Journal
- Accession number :
- 23679330
- Full Text :
- https://doi.org/10.7314/apjcp.2013.14.3.2127