Back to Search
Start Over
Sepsis-associated cholestasis in adult patients: a prospective study.
- Source :
-
The American journal of the medical sciences [Am J Med Sci] 2013 Dec; Vol. 346 (6), pp. 462-6. - Publication Year :
- 2013
-
Abstract
- Background: Sepsis-associated cholestasis is a common problem in neonatal patients. However, there are limited data related to sepsis-associated cholestasis in adults. In this study, the authors assessed the clinical characteristics, risk factors and outcome of adult patients with sepsis-associated cholestasis.<br />Methods: An observational prospective single-center study was conducted. A total of 608 patients with sepsis (66 patients with cholestasis and 542 without evidence of cholestasis) from January 1, 2005, to December 31, 2011, were included from the infectious disease unit. Demographic, clinical and laboratory information were recorded on admission for all patients. Additional data were also collected on the day of the 1st episode of bacteremia for patients who developed cholestasis. Accordingly, the organ dysfunction scores (Acute Physiology and Chronic Health Evaluation [APACHE] II and Sequential Organ Failure Assessment [SOFA]) were assessed on the same day.<br />Results: The mean age of the 608 patients was 49.3 ± 11.4 years (range, 22-83 years); 312 (51.3%) patients were men, 296 (48.7%) were women. The mean APACHE II and SOFA score were 15.2 ± 6 and 5.6 ± 2.3, respectively. Sepsis-associated cholestasis was strongly associated with older age, biomarkers of organ dysfunction and clinical composite scores (APACHE II and SOFA). Mortality was higher in patients with sepsis-associated cholestasis (10.6%) compared with subjects with sepsis without cholestasis (1.5%) (P < 0.05).<br />Conclusions: The authors found that sepsis-associated cholestasis affects the outcome of patients with sepsis in the infectious disease unit. Additional clinical studies are necessary to elucidate the pathology and pathophysiology of sepsis-associated cholestasis.
- Subjects :
- APACHE
Adult
Age Factors
Aged
China epidemiology
Cholestasis mortality
Female
Gram-Negative Bacteria classification
Gram-Negative Bacteria isolation & purification
Gram-Positive Bacteria classification
Gram-Positive Bacteria isolation & purification
Hospitalization
Humans
Incidence
Male
Middle Aged
Morbidity
Organ Dysfunction Scores
Prospective Studies
Risk Factors
Sepsis microbiology
Sepsis mortality
Cholestasis epidemiology
Cholestasis microbiology
Sepsis complications
Sepsis epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1538-2990
- Volume :
- 346
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The American journal of the medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 23689050
- Full Text :
- https://doi.org/10.1097/MAJ.0b013e3182955457