Back to Search
Start Over
Immunoglobulin M nephropathy in adults: a clinicopathological study.
- Source :
-
Iranian journal of kidney diseases [Iran J Kidney Dis] 2013 May 21; Vol. 7 (3), pp. 214-9. Date of Electronic Publication: 2013 May 21. - Publication Year :
- 2013
-
Abstract
- Introduction: There is no data specifically on the clinical and immunopathologic features of Immunoglobulin M nephropathy (IgMN) in adults with kidney diseases in Pakistan.<br />Materials and Methods: We retrospectively reviewed our adult native renal biopsy records from May 2001 to April 2010 and identified 57 cases out of a total of 1,753 records labeled as IgMN on final histopathological analysis. Among these, 41 cases were included in the present analysis. Their relevant data items were collected from the case files and biopsy reports.<br />Results: The mean age of this cohort was 30.21 ± 10.12 years. The male-female ratio was 1.15:1. The most common presentation was idiopathic nephrotic syndrome. Hematuria and hypertension at presentation were noted in 24 (58.5%) and 10 (24.4%) patients, respectively. The most common morphologic change was glomerular mesangial cell proliferation, found in 28 biopsies (68.3%). Mesangial matrix expansion was noted in 16 (39%). Minor glomerular alterations were noted in 5 cases (12.2%) and focal segmental glomerulosclerosis in 4 (9.8%). Immunofluorescence microscopy showed diffuse mesangial positivity of IgM in all specimens. Subdominant IgA was noted in 6 cases (14.6%). Complements C3 and C1q were found in 28 (68.3%) and 21 (51.2%) patients, respectively.<br />Conclusions: Our results show that IgMN is not very common in adults. Its clinicopathological spectrum is similar to that described from the neighboring countries, showing a spectrum of morphologic changes ranging from minor changes to focal segmental glomerulosclerosis.
- Subjects :
- Adult
Autoimmune Diseases epidemiology
Autoimmune Diseases pathology
Biomarkers analysis
Biopsy
Cell Proliferation
Complement C1q analysis
Complement C3 analysis
Cross-Sectional Studies
Female
Glomerulonephritis epidemiology
Glomerulonephritis pathology
Glomerulosclerosis, Focal Segmental epidemiology
Glomerulosclerosis, Focal Segmental immunology
Hematuria epidemiology
Hematuria immunology
Humans
Hypertension epidemiology
Hypertension immunology
Immunoglobulin A analysis
Kidney Glomerulus pathology
Male
Nephrotic Syndrome epidemiology
Nephrotic Syndrome immunology
Pakistan epidemiology
Retrospective Studies
Young Adult
Autoimmune Diseases immunology
Glomerulonephritis immunology
Immunoglobulin M analysis
Kidney Glomerulus immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1735-8604
- Volume :
- 7
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Iranian journal of kidney diseases
- Publication Type :
- Academic Journal
- Accession number :
- 23689154